Elena Dimitrova, Clemson University
“Control through canalization in modeling the innate immune response to ischemic injury”
Constriction of blood vessels in the extremities due to traumatic injury to halt excessive blood loss or resulting from pathologic occlusion can cause considerable damage to the surrounding tissues with significant morbidity and mortality. Optimal healing of damaged tissue relies on the precise balance of pro-inflammatory and pro-healing processes of innate inflammation. In this talk, we will present a discrete multiscale mathematical model that spans the tissue and intracellular scales, and captures the consequences of targeting various regulatory components. We take advantage of the canalization properties of some of the functions, which is a type of hierarchical clustering of the inputs, and use it as control to steer the system away from a faulty attractor and understand better the regulatory relations that govern the system dynamics.
Host: Melissa Kemp